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Med Chem. 2014Apr 24;57(8):3295­313. doi: 10.1021/jm500075d. Epub 2014Apr
15. PubMed PMID: 24673163.
86. Figueiras M, Coelho L, Kathryn J.Wicht, Sofia A Santos, João Lavrado, Jiri Gut,
Philip J. Rosenthal, Fátima Nogueira,Timothy J. Egan, Rui Moreira,Alexandra Paulo
(2015). N10, N11­di­alkylamine indolo[3,2­b]quinolines as hemozoin inhibitors: de-
sign, synthesis and antiplasmodial activity. Bioorganic & Medicinal Chemistry. 13 Fe-
bruary 2015
87. Nogueira F, Diez A, Radfar A, Pérez­Benavente S, do RosarioVE, Puyet A, Bau-
tista JM. Early transcriptional response to chloroquine of the Plasmodium
falciparum antioxidant defence in sensitive and resistant clones. Acta Trop.
2010 May;114(2):109­15. doi: 10.1016/j.actatropica.2010.01.013. Epub 2010 Feb
6. PubMed PMID: 20138820.
88. Ferreira ID, Nogueira F, Borges ST, do RosárioVE, Cravo P. Is the expression of
genes encoding enzymesof glutathione (GSH) metabolism involved in chloroquine
resistance in Plasmodium chabaudi parasites? Mol Biochem Parasitol. 2004
Jul;136(1):43­50. PubMed PMID: 15138066.
89. Nogueira F, Alves C, Estolio do Rosario V: Plasmodium falciparum multidrug
resistance protein (MRP) gene expression under chloroquine and mefloquine chal-
lenge. Journal of Cell andAnimal Biology 2008, 2:10­20.
90. Araujo MJ, Bom J, Capela R, Casimiro C, Chambel P, Gomes P, Iley J, Lopes
F,Morais J, Moreira R, de Oliveira E, do RosarioV,Vale N (2005). Imidazolidin­4­one
derivatives of primaquine as novel transmission­blocking antimalarials. J Med Chem.
Feb 10; 48(3):888­92.
91. Vale N, Matos J, Gut J, Nogueira F, do RosárioV, Rosenthal PJ, Moreira R, Go-
mes P. Imidazolidin­4­one peptidomimetic derivatives of primaquine: synthesis and
antimalarial activity. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4150­3. doi:
10.1016/j.bmcl.2008.05.076. Epub 2008 May 23. PubMed PMID: 18539459.
92. Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R,
Rosenthal PJ, Prudêncio M, Gomes P. Novel potent metallocenes against liver stage
malaria. AntimicrobAgents Chemother. 2012Mar; 56(3):1564­70. d o i :
10.1128/AAC.05345­11. Epub 2011 Dec 12. PubMed PMID: 22155838; Pub-
Med Central PMCID: PMC3294896.
93. Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J,Valderramos SG,
McNae I, Cheesman S, do RosarioV, Carter R, Fidock DA, Cravo P. Gene encoding
a deubiquitinating enzyme is mutated in artesunate­and chloroquine­resistant rodent
malaria parasites. Mol Microbiol. 2007 Jul; 65(1):27­40. PubMed PMID: 17581118;
PubMed Central PMCID: PMC1974797.
94. Hunt P, Martinelli A, Modrzynska K, Borges S, Creasey A, Rodrigues L,Be-
raldi D, Loewe L, Fawcett R, Kumar S,Thomson M,Trivedi U, OttoTD, PainA, Blax-
ter M, Cravo P. Experimental evolution, genetic analysis and genome re­sequen-
cing reveal the mutation conferring artemisinin resistance in an isogenic lineage of
malaria parasites. BMC Genomics. 2010 Sep 16;11:499. doi: 10.1186/1471­2164­11­
499. PubMed PMID: 20846421; PubMed Central PMCID: PMC2996995.
95. Borges S, Cravo P, Creasey A, Fawcett R, Modrzynska K, Rodrigues
L, Martinelli A, Hunt P. (2011). Genomewide scan reveals amplification of mdr1
as a common denominator of resistance to mefloquine, lumefantrine, and arte-
misinin in Plasmodium chabaudi malariaparasites.Antimicrob Agents C h e m
ther. Oct;55(10):4858­65. doi:10.1128/AAC.01748­10. Epub 2011 Jun 27. PubMed
PMID: 21709099; PubMed Central PMCID: PMC3186966.
96. do Céu de Madureira M, Paula MartinsA, Gomes M, Paiva J, Proença da Cunha
A, do RosárioV.Antimalarial activity of medicinal plants used in traditional medicine
in S.Tomé and Príncipe islands. J Ethnopharmacol. 2002 Jun;81(1):23­9.
97. Ramalhete C, da Cruz FP, Lopes D, Mulhovo S, RosárioVE, Prudêncio M, Fer-
reira MJ.Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium
infections. Bioorg Med Chem. 2011 Dec15;19(24):7474­81. doi: 10.1016/j.
bmc.2011.10.044. Epub 2011 Oct 20. PubMed PMID: 22071523.
98. Portela C, Afonso CM, Pinto MM, Lopes D, Nogueira F, do Rosário V.
Synthesis and antimalarial properties of new chloro­9H­xanthones with an aminoalkyl
side chain. Chem Biodivers. 2007 Jul;4(7):1508­19. PubMed PMID: 17638332.
99. Carrasco MP, NewtonAS, Gonçalves L, GóisA, Machado M, Gut J, Nogueira F,
HänscheidT, Guedes RC, dos Santos DJ, Rosenthal PJ,Moreira R. Probing the aurone
scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.
Eur J Med Chem. 2014 Jun 10;80:523­34. doi: 10.1016/j.ejmech.2014.04.076.
Epub 2014Apr 28. PubMed PMID: 24813880.
100. Gomes A, Pérez B,Albuquerque I, Machado M, Prudêncio M, Nogueira F,Tei-
xeira C, Gomes P. N­cinnamoylation of antimalarial classics: quinacrine analogues with
decreased toxicity and dual­stage activity. ChemMedChem. 2014 Feb;9(2):305­10.
doi: 10.1002/cmdc.201300459. Epub 2013 Dec 27. PubMed PMID: 24474655.
101. Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd,
Gut J, Rosenthal PJ, Moreira R, PauloA. Bis­alkylamine quindolone derivatives as new
antimalarial leads.BioorgMed Chem Lett. 2010 Oct 1;20(19):5634­7. d o i :
10.1016/j.bmcl.2010.08.043. Epub 2010Aug 12. PubMed PMID: 20801652.
102. Miranda D, Capela R,Albuquerque IS, Meireles P, Paiva I, Nogueira F,Amewu
R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M,
O’Neill PM, Lopes F Novel endoperoxide­based transmission­blocking antimala-
rials with liver­ and blood­schizontocidal activities. ACS Med Chem Lett. 2013
Dec 20;5(2):108­12. doi: 10.1021/ml4002985. eCollection 2014 Feb 13. PubMed
PMID: 24900781; PubMed Central PMCID: PMC4027774.
103. Almeida AP & Billingsley PF (1998). Induced immunity against the mosquito
Anopheles stephensi Liston (Diptera: Culicidae): effects on mosquito survival and
fecundity. Int J Parasitol. Nov;28(11):1721­31.
104. Félix RC, Silveira H (2011). The Interplay between Tubulins and P450
Cytochromes during Plasmodium berghei Invasion of Anopheles gambiae Mid-
gut. PLoS ONE 6: e24181.
105. Silveira H, Gabriel A, Ramos S, Palma J, Felix R, Custódio A, Collins LV. CpG­
containing oligodeoxynucleotides increases resistance of Anopheles mosquitoes to
Plasmodium infection. Insect Biochem Mol Biol. 2012 Oct;42(10):758­65. doi:
10.1016/j.ibmb.2012.07.003. Epub 2012 Jul 31. PubMed PMID: 22885118.
106. Almeida AP & Billingsley PF (2002). Induced immunity against the mosquito
Anopheles stephensi (Diptera: Culicidae): effects of cell fraction antigens on survi-
val, fecundity, and transmission of Plasmodium berghei (Eucoccidiida: Plasmodiidae)
transmission. J Med Entomol 39:207­14.
107.Abrantes P, Lopes LF, do RosárioVE, Silveira H (2005). Effect of chloroquine on
the expression of genes involved in the mosquito immune response to Plasmodium
infection. Insect Biochem Mol Biol 35:1124­1132.
108.Abrantes P, Dimopoulos G, Grosso AR, do RosárioVE, Silveira H (2008) Chlo-
roquine mediated modulation of Anopheles gambiae gene expression. PLoS One
3:e2587.
109. Ribeiro H, Batista JL, Ramos HC, Pires CA, Champalimaud JL, Costa JM,
Araújo C, Mansinho K, Pina MC (1989).An attempt to infect Anopheles atroparvus
from Portugal with African Plasmodium falciparum. Revista Portuguesa de Doenças
Infecciosas 12:81­82.
110. Félix RC, Müller P, Ribeiro V, Ranson H, Silveira H. (2010). Plasmodium in-
fection alters Anopheles gambiae detoxification gene expression. BMC genomics.
11:312.